Brian Pierce

Portrait of Brian Pierce

Brian Pierce

Cell Biology & Molecular Genetics and IBBR Associate Professor; BISI Computational Biology, Bioinformatics, & Genomics (CBBG) Director

Biography

Prior to joining the University of Maryland in 2014, I was a research faculty member at the University of Massachusetts Medical School, following two years as a Senior Scientist at Pfizer. I received my Ph.D. in Bioinformatics from Boston University in 2008 and a B.S. in Physics and Computer Science from Duke University.


Teaching

  • BSCI411: Bioinformatics and Integrated Genomics
  • CBMG688G: Computational Structural Biology

Graduate Program Affiliations


Research Interests

My lab focuses on computational structural biology, with a particular emphasis on modeling and design of immune recognition, including antibodies, T cell receptors, and structure-based vaccine design. We develop and utilize artificial intelligence and physics-based approaches, and we actively share our software tools and curated structural databases with the research community. My laboratory is based at the University of Maryland Institute for Bioscience and Biotechnology Research in Rockville. 


Education

  • Ph.D., Bioinformatics, Boston University, 2008
  • B.S., Physics and Computer Science, Duke University, 2000

All Publications

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BISI Concentration Areas

CBBG

MOCB


Latest Papers

Dynamic S-Acylation of GSDMA Regulates Pyroptosis.

| ACS Chemical Biology
Author(s): Tao Z, Thakare RP, Cheung M, et. al
UMD Author(s): Brian Pierce


TEpiNom: A computational framework integrating population data to prioritize Plasmodium falciparum T cell epitopes.

| Vaccine
Author(s): Laurenson AJ, Pierce BG, Takala-Harrison S, et. al
UMD Author(s): Brian Pierce


Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent.

| The Journal of general virology
Author(s): Mimms JL, Sinnis-Bourozikas A, Felbinger NR, et. al
UMD Author(s): Brian Pierce


Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes.

| Nature Communications
Author(s): Yuan P, Chen G, Li Y, et. al
UMD Author(s): Brian Pierce


Evaluation of AlphaFold modeling for elucidation of nanobody-peptide epitope interactions.

| The Journal of biological chemistry
Author(s): Sachdev S, Roy S, Saha SJ, et. al
UMD Author(s): Brian Pierce


A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

| Structure (London, England : 1993)
Author(s): Sajadi MM, Abbasi A, Tehrani ZR, et. al
UMD Author(s): Brian Pierce


RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication.

| Pathogens (Basel, Switzerland)
Author(s): Lin S, Sallapalli BT, Chang P, et. al
UMD Author(s): Brian Pierce


AlphaFold and Docking Approaches for Antibody–Antigen and Other Targets: Insights From CAPRI Rounds 47–55

| Proteins: Structure, Function, and Bioinformatics
Author(s): Ragul Gowthaman, Minjae Park, Rui Yin, et. al
UMD Author(s): Brian Pierce


TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions

| Nucleic Acids Research
Author(s): Valerie Lin, Melyssa Cheung, Ragul Gowthaman, et. al
UMD Author(s): Brian Pierce