Elissa Lei

Portrait of Elissa Lei

Elissa Lei

NIH NIDDK Laboratory of Biochemistry & Genetics' Nuclear Organization and Gene Expression Section Chief

I earned my bachelor's degree in Molecular Biology from The University of Texas at Austin and my Ph.D. from Harvard Medical School studying mRNA nuclear export.  I went on to perform postdoctoral training at Johns Hopkins University where I began studying regulatory mechanisms of chromatin organization and gene expression.  I started my own research lab at the National Institutes of Health in 2006 and have supervised a number of UMD Ph.D. students along with postdoctoral and postbaccalaureate fellows.  We utilize a variety of model organisms and both wet bench and computational approaches. The work performed in my laboratory will help determine how the 3-dimensional organization of DNA within each cell affects cellular function and identity throughout development.

BISI Concentration Areas

CBBG

MOCB


Latest Papers

Effete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator.

| BMC biology
Author(s): Chen S, Yang D, Lei EP
UMD Author(s): Elissa Lei


Unique territorial and compartmental organization of chromosomes in the holocentric silkworm.

| The EMBO Journal
Author(s): Gil J Jr, Navarrete E, Hockens C, et. al
UMD Author(s): Elissa Lei


CTCF regulates global chromatin accessibility and transcription during rod photoreceptor development.

| Proceedings of the National Academy of Sciences of the United States of America
Author(s): Chen D, Keremane S, Wang S, et. al
UMD Author(s): Elissa Lei


Chromatin insulator mechanisms ensure accurate gene expression by controlling overall 3D genome organization.

| Current opinion in genetics & development
Author(s): Bhattacharya M, Lyda SF, Lei EP
UMD Author(s): Elissa Lei


3D genome organization.

| Scientific Reports
Author(s): Silahtaroglu A, Bridger JM, Lei EP
UMD Author(s): Elissa Lei


DiffChIPL: a differential peak analysis method for high-throughput sequencing data with biological replicates based on limma.

| Bioinformatics (Oxford, England)
Author(s): Chen Y, Chen S, Lei EP
UMD Author(s): Elissa Lei


Isha is a su(Hw) mRNA-binding protein required for gypsy insulator function.

| G3 (Bethesda, Md.)
Author(s): Bag I, Chen Y, D'Orazio K, et. al
UMD Author(s): Elissa Lei


NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization.

| Nucleic Acids Research
Author(s): Chen S, Rosin LF, Pegoraro G, et. al
UMD Author(s): Elissa Lei


Transposable element landscapes in aging Drosophila.

| Plos Genetics
Author(s): Yang N, Srivastav SP, Rahman R, et. al
UMD Author(s): Elissa Lei


Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males.

| Proceedings of the National Academy of Sciences of the United States of America
Author(s): Rosin LF, Chen D, Chen Y, et. al
UMD Author(s): Elissa Lei


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