Elissa Lei

Portrait of Elissa Lei

Elissa Lei

NIH NIDDK Laboratory of Biochemistry & Genetics' Nuclear Organization and Gene Expression Section Chief

I earned my bachelor's degree in Molecular Biology from The University of Texas at Austin and my Ph.D. from Harvard Medical School studying mRNA nuclear export.  I went on to perform postdoctoral training at Johns Hopkins University where I began studying regulatory mechanisms of chromatin organization and gene expression.  I started my own research lab at the National Institutes of Health in 2006 and have supervised a number of UMD Ph.D. students along with postdoctoral and postbaccalaureate fellows.  We utilize a variety of model organisms and both wet bench and computational approaches. The work performed in my laboratory will help determine how the 3-dimensional organization of DNA within each cell affects cellular function and identity throughout development.

Latest Papers

3D genome organization.

| Scientific Reports
Author(s): Silahtaroglu A, Bridger JM, Lei EP
UMD Author(s): Elissa Lei


DiffChIPL: a differential peak analysis method for high-throughput sequencing data with biological replicates based on limma.

| Bioinformatics (Oxford, England)
Author(s): Chen Y, Chen S, Lei EP
UMD Author(s): Elissa Lei


Isha is a su(Hw) mRNA-binding protein required for gypsy insulator function.

| G3 (Bethesda, Md.)
Author(s): Bag I, Chen Y, D'Orazio K, et. al
UMD Author(s): Elissa Lei


NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization.

| Nucleic Acids Research
Author(s): Chen S, Rosin LF, Pegoraro G, et. al
UMD Author(s): Elissa Lei


Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males.

| Proceedings of the National Academy of Sciences of the United States of America
Author(s): Rosin LF, Chen D, Chen Y, et. al
UMD Author(s): Elissa Lei


Transposable element landscapes in aging Drosophila.

| Plos Genetics
Author(s): Yang N, Srivastav SP, Rahman R, et. al
UMD Author(s): Elissa Lei


Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling.

| Nature Communications
Author(s): Chen D, McManus CE, Radmanesh B, et. al
UMD Author(s): Elissa Lei


Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori.

| Plos Genetics
Author(s): Rosin LF, Gil J Jr, Drinnenberg IA, et. al
UMD Author(s): Elissa Lei


M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.

| Nature Communications
Author(s): Bag I, Chen S, Rosin LF, et. al
UMD Author(s): Elissa Lei


Correction: The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila (doi:10.1242/jcs.226092).

| Journal of Cell Science
Author(s): Bag I, Dale RK, Palmer C, et. al
UMD Author(s): Elissa Lei


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