Jeff Maltas

Portrait of Jeff Maltas

Jeff Maltas

Biology Assistant Professor

Start Date

July 2026


Graduate Program Affiliations


Research Interests

My group uses a combination of theoretical and experimental approaches to study the short-term eco-evolutionary dynamics that emerge in large, rapidly evolving populations such as bacteria, yeast, and cancer. We leverage recent technological advances that have revolutionized our ability to study complex, evolving systems with unprecedented resolution.

Work from multiple disciplines – including ecology, statistical physics, and economics – reveals that complex systems are often dominated by emergent behavior not easily recognizable from the behavior of the constituent parts. In a similar spirit, using tools from population genetics, game theory, and statistical physics, we aim to understand how evolution at the population-level emerges from its constituent parts: competition/cooperation between lineages, population density, spatial heterogeneity, and fluctuating environments.

Critically, many of the most challenging public health concerns worldwide are the result of evolving diseases such as cancer, COVID-19, and antibiotic resistance. As such it is imperative to translate our understanding of these fundamental processes into a testable theoretical framework to help us better forecast, and ultimately control, the evolution of these systems.

Latest Papers

In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kras-driven lung adenocarcinoma

| Genes & Diseases
Author(s): Athar Khalil, Trang Dinh, Meaghan Parks, et. al
UMD Author(s): Jeff Maltas


Linezolid and levofloxacin: an uncommon pairing that suppresses evolution of resistance in E. faecalis

| FEMS Microbes
Author(s): Noah M Schlachter, Keanu Guardiola Flores, Kevin B Wood, et. al
UMD Author(s): Jeff Maltas


In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Ras-driven lung adenocarcinoma

| Genes & Diseases
Author(s): Athar Khalil, Trang Dinh, Meaghan Parks, et. al
UMD Author(s): Jeff Maltas


Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

| Science advances
Author(s): Eshan S. King, Anna E. Stacy, Davis T. Weaver, et. al
UMD Author(s): Jeff Maltas


Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments

| PLOS Biology
Author(s): Jeff Maltas, Tobias Bollenbach, Anh Huynh, et. al
UMD Author(s): Jeff Maltas


Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance

| PRX Life
Author(s): Jeff Maltas, Dagim Shiferaw Tadele, Arda Durmaz, et. al
UMD Author(s): Jeff Maltas


Author Correction: Drug dependence in cancer is exploitable by optimally constructed treatment holidays

| Nature Ecology & Evolution
Author(s): Jeff Maltas, Shane T. Killarney, Katherine R. Singleton, et. al
UMD Author(s): Jeff Maltas


Heterogeneous collateral effects in daptomycin-resistantE. faecalis


Author(s): Anh Huynh, Jeff Maltas, Kevin B. Wood
UMD Author(s): Jeff Maltas


Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus


Author(s): Kyle J. Card, Dena Crozier, Arda Durmaz, et. al
UMD Author(s): Jeff Maltas


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