Patrick Dolan

Portrait of Patrick Dolan

Patrick Dolan

NIH NIAID Quantitative Virology and Evolution Unit Chief

Research Interests

  • Virus-host dynamics at single-cell resolution
  • Virus evolution within and across hosts
  • Systems biology of virus infection
  • RNA Viruses: Picornaviridae, Flaviviridae, and others

BISI Concentration Areas

Molecular and Cellular Biology

Latest Papers

Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication


Author(s): Patrick Dolan, William Bakhache, Walker Symonds-Orr
UMD Author(s): Patrick Dolan


Comparative Analysis of Deep Mutational Scanning Datasets in Enteroviruses A and B Identifies Functional Divergence and Therapeutic Targets


Author(s): Patrick Dolan, Beatriz Álvarez-Rodríguez, William Bakhache, et. al
UMD Author(s): Patrick Dolan


Novel reporter constructs to accelerate antiviral and therapeutic discovery for Enterovirus-A71

| Antiviral Research
Author(s): William Bakhache, Ann Shen, Walker Symonds-Orr, et. al
UMD Author(s): Patrick Dolan


Constraint in West Nile virus envelope protein across mosquito, human, and avian host cell environments

| Virus Evolution
Author(s): Jack Dorman, William Bakhache, Theodore C Pierson, et. al
UMD Author(s): Patrick Dolan


Strain-specific tropism and transcriptional responses of enterovirus D68 infection in human spinal cord organoids

| Frontiers in microbiology
Author(s): Nathânia Dábilla, Sarah Maya, Colton McNinch, et. al
UMD Author(s): Patrick Dolan


Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution

| Nature Microbiology
Author(s): William Bakhache, Walker Symonds-Orr, Lauren McCormick, et. al
UMD Author(s): Patrick Dolan


Structure and dynamics of enterovirus genotype networks

| Science advances
Author(s): Dábilla, N., Dolan, P.T.
UMD Author(s): Patrick Dolan


C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire

| Science Immunology
Author(s): Kosik, I., Da Silva Santos, J., Angel, M., et. al
UMD Author(s): Patrick Dolan


Uncovering Structural Plasticity of Enterovirus A through Deep Insertional and Deletional Scanning


Author(s): Dolan P, Bakhache W, Orr W, et. al
UMD Author(s): Patrick Dolan


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