Seth Dickey

Research Interests

Antimicrobial resistance (AMR) among bacterial pathogens claims millions of lives and cost billions of dollars every year. New targets and strategies are desperately needed to blunt the societal impact of AMR on human and animal health. The Dickey lab employs bacterial genetics, molecular biology, membrane and protein biochemistry techniques to understand the physiology, virulence, and antibiotic resistance of pathogenic bacteria as well as the mechanisms of new antimicrobials.

Current Projects:

• Novel antimicrobials: We are focusing on understanding the mechanisms and biosynthesis of a new class of antimicrobials.
• Pathway analysis: Nearly a quarter of the MRSA genes encoded in the core genome are poorly understood. We are developing advanced genetic approaches to probe this dark genetic matter with the goal of identifying new therapeutic targets or informing combinatorial treatment approaches.