Shaik Rahaman

The Rahaman laboratory is interested in elucidating the molecular signaling events underlying the pathogenesis of various inflammatory diseases, specifically, atherosclerosis and fibrosis. Using a multipronged approach involving cells from null mouse strains (apoE null, apoE/Trpv4 double null, and Trpv4fl/fl mac null), in vivo and in vitro assay systems, intravital microscopy, mouse models of atherosclerosis and fibrosis, in vivo and in vitro measurements of Ca2+ flux, atomic force microscopy, traction force microscopy, fluorescent imaging techniques, and various genetic/molecular/physiological approaches, the Rahaman lab investigates how Ca2+-elicited signaling and mechanotransduction regulate fibrogenesis and atherogenesis.