Kan Cao

Portrait of Kan Cao

Kan Cao

Cell Biology & Molecular Genetics Professor
kcao@umd.edu 2114 Bioscience Research Bldg.
301 405 3016
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Biography

Kan Cao, Ph.D., received her B.S. in Biology from Nanjing University and her Ph.D. in Biology from Johns Hopkins University. She completed postdoctoral training in genomics at the National Institutes of Health. Dr. Cao is a Professor and Associate Chair of Cell Biology and Molecular Genetics at the University of Maryland.

Dr. Cao’s research focuses on the molecular and cellular mechanisms of Hutchinson–Gilford Progeria Syndrome (HGPS), a rare premature aging disorder, and fundamental processes of human aging. Her work has contributed to understanding how mutations in the lamin A gene disrupt nuclear architecture and drive disease, with broader implications for laminopathies and age-related pathologies. Her laboratory integrates cell biology, stem cell models, and genomic approaches to study nuclear structure and function. Her contributions have been recognized with multiple honors, including the Ellison Medical Foundation New Scholar in Aging Award, University of Maryland faculty awards, entrepreneurship distinctions, and induction as a Senior Member of the National Academy of Inventors.


Graduate Program Affiliations


Research Interests

Hutchinson Gilford progeria, telomere and cellular senescence, alternative splicing and human aging


Education

  • Ph.D., Johns Hopkins University, 2005

All Publications

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Latest Papers

Deep Profiling of the Aging Proteome Depicts Neuroinflammation, Synaptic Function, and Phosphorylation in an Accelerated Alzheimer's Disease Cell Model

| Molecular & Cellular Proteomics
Author(s): Emma Gentry, Md Tarikul Islam, Huijing Xue, et. al
UMD Author(s): Kan Cao


Angiopoietin‐2 reverses endothelial cell dysfunction in progeria vasculature

| Aging Cell
Author(s): Sahar Vakili, Elizabeth K. Izydore, Leonhard Losert, et. al
UMD Author(s): Kan Cao


Angiopoietin-2: A Therapeutic Target for Vascular Protection in Hutchinson–Gilford Progeria Syndrome

| International Journal of Molecular Sciences
Author(s): Sahar Vakili, Kan Cao
UMD Author(s): Kan Cao


Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms

| NAR Genomics and Bioinformatics
Author(s): Reynold Yu, Huijing Xue, Wanru Lin, et. al
UMD Author(s): Kan Cao, Wanru Lin


Development of an accelerated cellular model for early changes in Alzheimer’s disease

| Scientific Reports
Author(s): Huijing Xue, Sylvester Gate, Emma Gentry, et. al
UMD Author(s): Wolfgang Losert, Kan Cao


Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome

| Scientific Reports
Author(s): Nadia O. Abutaleb, Leigh Atchison, Leandro Choi, et. al
UMD Author(s): Kan Cao