Najib M. El-Sayed

Portrait of Najib M. El-Sayed

Najib M. El-Sayed

Cell Biology & Molecular Genetics Professor

Director, Integrated Life Sciences Honors Program

Biography & Research Interests

Dr. Najib El-Sayed is a Professor of Cell Biology and Molecular Genetics at the University of Maryland, with a joint appointment in the Center for Bioinformatics and Computational Biology at UMIACS. He is the Director of Integrated Life Sciences (ILS) in the Honors College, Director of the Brain & Behavior Institute - Advanced Genomic Technologies Core (BBI-AGTC), and Director of Bioinformatics at the University of Maryland Institute for Health Computing.

He received his Ph.D. from Yale University in Molecular Parasitology and then trained as a Howard Hughes Medical Institute post-doctoral fellow in the laboratory of John Donelson at the University of Iowa. In 1998, he joined The Institute for Genomic Research (TIGR) in Rockville, Maryland where he led the sequencing, annotation, and comparative and functional genomic analyses of several human pathogens. He has been at the University of Maryland since 2006. He was the founding director of the Next-Generation Sequencing Core at the University, as well as the Computational Biology, Bioinformatics and Genomics graduate concentration area of studies.

Dr. El-Sayed’s research program is focused on the study of the biology of parasitism and host-pathogen interactions using genomic and bioinformatics approaches with the ultimate goal of better understanding infection and survival mechanisms. These approaches include the development and application of molecular, computational and genomic tools. In the long term, his research will contribute to better diagnosis, prevention and therapeutics of parasite- and bacteria-caused diseases in humans, animals and plants. He has published over 100 research papers and serves on several editorial boards. He also serves on NIH’s Genomics, Computational Biology and Technology (GCAT) study section as well as on the Scientific Advisory Board for the National Institute of Allergy and Infectious Diseases’ Genome Sequencing Centers for Infectious Diseases.


Teaching

  • BISI620: Bioinformatics and Genomics
  • BISI622: Programming for Biology
  • HLSC227: Topics in Scientific Integrity and Medical Ethics
  • HLSC280: Integrative and Quantitative Concepts in Biology
  • BSCI348R: Microbiology Internship

Graduate Program Affiliations


Education

  • Ph.D., Yale University School of Medicine, 1993

All Publications

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Latest Papers

Identification of Pseudomonas aeruginosa genetic determinants that connect redox metabolism to alginate biosynthesis


Author(s): Soo-Kyoung Kim, Nishad Thamban Chandrika, Ashton Trey Belew, et. al
UMD Author(s): Najib M. El-Sayed, Vincent Lee


Interplay of human macrophage response and natural resistance of infection by L. (V.) panamensis to pentavalent antimony

| PLOS Neglected Tropical Diseases
Author(s): Olga Lucía Fernández, Ulisses Gazos Lopes, Ashton Trey Belew, et. al
UMD Author(s): Najib M. El-Sayed


The Streptococcus pyogenes stand-alone regulator RofA exhibits characteristics of a PRD-containing virulence regulator

| Infection and Immunity
Author(s): Meaghan T. Hart, Joseph S. Rom, Yoann Le Breton, et. al
UMD Author(s): Najib M. El-Sayed


Innate biosignature of treatment failure in human cutaneous leishmaniasis


Author(s): Maria Adelaida Gómez, Ashton Trey Belew, Deninson Vargas, et. al
UMD Author(s): Najib M. El-Sayed


Consolidation of a Molecular Signature of Healing in Cutaneous Leishmaniasis Is Achieved during the First 10 Days of Treatment

| The Journal of Immunology
Author(s): Lina Giraldo-Parra, David E Rebellón-Sánchez, Adriana Navas, et. al
UMD Author(s): Najib M. El-Sayed


Characterization of the Entner-Doudoroff pathway in Pseudomonas aeruginosa catheter-associated urinary tract infections

| Journal of bacteriology
Author(s): Nour El Husseini, Solomon A. Mekonnen, Cherisse L. Hall, et. al
UMD Author(s): Najib M. El-Sayed, Vincent Lee


Characterization of the Entner-Douderoff Pathway inPseudomonas aeruginosaCatheter-associated Urinary Tract Infections


Author(s): Nour El Husseini, Solomon A. Mekonnen, Cherisse L. Hall, et. al
UMD Author(s): Najib M. El-Sayed


Catheter-associated urinary tract infection by Pseudomonas aeruginosa progresses through acute and chronic phases of infection

| Proceedings of the National Academy of Sciences
Author(s): Solomon A. Mekonnen, Nour El Husseini, Asan Turdiev, et. al
UMD Author(s): Najib M. El-Sayed, Vincent Lee, Jared Carter


Loss of rpoE Encoding the δ-Factor of RNA Polymerase Impacts Pathophysiology of the Streptococcus pyogenes M1T1 Strain 5448

| Microorganisms
Author(s): Joseph S. Rom, Yoann Le Breton, Emrul Islam, et. al
UMD Author(s): Najib M. El-Sayed


Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization

| mBio
Author(s): Lindsey R. Burcham, Madeline S. Akbari, Norhan Alhajjar, et. al
UMD Author(s): Najib M. El-Sayed