Sougata Roy

Portrait of Sougata Roy

Sougata Roy

Cell Biology & Molecular Genetics Associate Professor

Biography

Dr. Sougata Roy earned his Ph.D. in Biochemistry and Molecular Biology from the Indian Institute of Science, Bangalore, following earlier training with an M.Sc. in Zoology from the University of Calcutta and an M.Tech. in Biotechnology from Jadavpur University. He completed his postdoctoral research at the University of California, San Francisco, where he investigated novel mechanisms of long-range cell–cell communication and helped establish cytoneme-mediated signaling in the Drosophila model system. Dr. Roy joined the University of Maryland faculty in 2014 and was awarded tenure in 2020. His research career has been supported by several prestigious grants, including the NIH Pathway to Independence (K99/R00) Award and the Maximizing Investigators’ Research Award (MIRA) from NIGMS.


Teaching

  • Cell Biology (BSCI420/421)
  • Molecular Genetics: Bioinformatics and Computation Biology (CBMG699D)
  • Genetics: Cell Biology I - Structure and Function (CBMG688D)

Graduate Program Affiliations


Research Interests

Dr. Roy’s research program focuses on uncovering the cellular and molecular mechanisms that govern tissue patterning and morphogenesis during development. His laboratory is recognized for pioneering work on cytoneme-mediated growth factor signaling, a contact-dependent mechanism that enables communication between cells over long distances. Using Drosophila genetics, genome editing, and high-resolution live imaging, his group has revealed how Fibroblast Growth Factor (FGF) signals are precisely prepared, transported, and interpreted through cytoneme-mediated interactions to control cell fate, polarity, and tissue organization. In addition to his research contributions, Dr. Roy is deeply committed to mentoring and training students at all levels and actively serves the broader scientific community through grant review panels, peer review, conference leadership, and outreach initiatives.

Funding: NIH/NIGMS and NIH/NHLBI


Education

  • Ph.D., Indian Institute of Science, Bangalore, India, 2006
  • Postdoctoral Fellowship, Department of Biochemistry and Cardiovascular Research Institute, University of California, San Francisco, 2006-2014

All Publications

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Latest Papers

Cytoneme feedback ensures signaling specificity when multiple ligands converge on a common receptor


Author(s): Akshay Patel, Molly Maranto, Hind Hitti, et. al
UMD Author(s): Sougata Roy


GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion

| Nature Communications
Author(s): Lijuan Du, Alex Sohr, Yujia Li, et. al
UMD Author(s): Sougata Roy


Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

| Nature Communications
Author(s): Akshay Patel, Yicong Wu, Xiaofei Han, et. al
UMD Author(s): Sougata Roy


GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion


Author(s): Lijuan Du, Alex Sohr, Yujia Li, et. al
UMD Author(s): Sougata Roy


Drosophila FGF cleavage is required for efficient intracellular sorting and intercellular dispersal

| Journal of Cell Biology
Author(s): Alex Sohr, Lijuan Du, Ruofan Wang, et. al
UMD Author(s): Sougata Roy


Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

| eLife
Author(s): Lijuan Du, Alex Sohr, Ge Yan, et. al
UMD Author(s): Sougata Roy


An Efficient Strategy for Generating Tissue-specific Binary Transcription Systems in Drosophila by Genome Editing.

| Journal of visualized experiments : JoVE
Author(s): Du L, Zhou A, Sohr A, et. al
UMD Author(s): Sougata Roy


Imaging Cytonemes in Drosophila Embryos.

| Methods in molecular biology (Clifton, N.J.)
Author(s): Du L, Roy S
UMD Author(s): Sougata Roy


Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome

| Science Signaling
Author(s): Risa Kashima, Patrick L. Redmond, Prajakta Ghatpande, et. al
UMD Author(s): Sougata Roy


Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis.

| Developmental Biology
Author(s): Du L, Zhou A, Patel A, et. al
UMD Author(s): Sougata Roy